the best PRS was with European selected variants and fixed-effects meta-analysis or European weights (r = 0.73; 95% CI = [0.72, 0.74]). For individuals with intermediate (20%–80%) or low (<20%) European ancestry, the most accurate PRS was from using African selected variants and weights from a fixed-effects meta-analysis (r = 0.68; 95% CI = [0.67, 0.68] and 0.71; 95% CI = [0.70, 0.72], respectively). Again, no benefit was observed with the inclusion of local ancestry-specific weights for any set of PRS variants. Using a more stringent p value threshold and including fewer variants into the PRS did not result in a change of the best PRS variants and weights (Figure S2).
