al. 2003). Recent studies suggest that this EtOH action involves increased receptor desensitization (Möykkynen et al. 2003, 2009), and thus the drug has little impact on AMPAR-mediated synaptic responses at most synapses given that desensitization does not contribute to the amplitude or time course of excitatory postsynaptic currents (EPSCs) (Lovinger et al. 1990; Ariwodola et al. 2003, but see Nie et al. 1993, 1994; Roberto et al. 2004b; Mameli et al. 2005; Zhu et al. 2007).
