Peroxisome proliferator-activated receptor α (PPARα) is a major to regulator for hepatic lipid metabolism. Interestingly, the basal level of PPARα was elevated in the cyp2a5−/− mice (ref. 11–12). Using Pparα and Cyp2a5 double knockout (P-A-) mice, we found that CYP2A cooperates with PPARα in mice to protect against alcoholic fatty liver (ref. 12). It is well known that PPARα regulates fatty acid oxidation and protects against non-alcoholic fatty liver (ref. 14–15). PPARα activation prevent obesity in ob/ob obese mice (ref. 16) and PPARα absence in ob/ob obese mice make the mice more obese (ref. 17), suggesting that PPARα may also protect against obesity. In this study we examined whether CYP2A interacts with PPARα to regulate obesity and non-alcoholic fatty liver.
