The genetic analyses found evidence for genetic linkage between this phenotype and the chromosome 1 locus that was also linked to alcohol dependence and low level of response to alcohol (Nurnberger et al. 2001). In fact, of the traits analyzed, the “alcoholism or depression” phenotype showed the strongest association with that locus.3 The COGA findings regarding the association between alcoholism and depression are discussed in more detail in the article by Nurnberger and colleagues, pp. 233–240, in this issue.
