The involvement of DS-epi1 in NC migration in Xenopus embryos prompted us to investigate a potential link between DSE expression and tumorigenic properties in two human NC-derived cancers (Fig. S9). Gene set enrichment analysis of the expression datasets from both neuroblastoma and metastatic melanoma (n=498 and 44, respectively) demonstrated that DSE expression correlated with genes associated with EMT, mesenchymal and invasive phenotypes, as well as genes involved in metastasis. These findings indicate a potential role of DS-epi1 in NC-tumor development, which warrants further investigation.
