(Text S1). If complete disease status is known for all siblings, parents, grandparents, aunts, uncles and cousins then the maximum AUC that could be achieved is 0.71, translating to a genomic profile that explains 0.21 of the genetic variance (Table S1). In practice, the AUC for a risk predictor based on rs1061170 a single nucleotide polymorphism in the complement factor H (CFH) gene was 0.69 [23] (and was approximately equal for advanced AMD cases vs controls and all AMD cases vs controls). From equations 4–6, = 0.12, λS [x] = 1.17, = 0.17 and (λS [x] – 1)/(λS – 1) = 0.15.
