interval, two previously identified associations in the SCN10A gene have consistent directions of effect with African Americans (Fig. 1, Supplementary Table 2). Non-synonymous variant rs6795970 (in the SCN10A gene) has been recently reported to have an association with increased PR interval in Asian and European-descent populations (Holm et al. 2010; Pfeufer et al. 2010). In African Americans the magnitude of this effect (β= 3.67) is consistent with Europeans (β= 5.17) (Fig. 1, Supplementary Table 2).
