boosting the significance of the CHRNB3 SNP rs4950 to p=0.022, rs2304297 in CHRNA6 was also nominally associated with tobacco dependence (p=0.023). Results of analysis of all subjects are shown in the right half of Table 7. In the singletons, there was modest evidence for rs2304297 using an additive model (p=0.028), and modest evidence for rs13280604 and rs892413 with a recessive model (p=0.044 and p=0.024). After combining p-values with the PBAT sibpair results, there is some evidence for association of rs2304297 in CHRNA6 (p=0.011).
