In summary, we showed that PGSAUD was negatively associated with the probability of 12-month and non-abstinent remission even after adjusting for AUD severity, family history of remission, and treatment history in COGA EA. More work is needed to understand the influence of PGSAUD on remission probability, particularly its importance in relation to and interplay with family and treatment history. Although we tested a high-risk familial sample and two cohorts from Indiana Biobank in the current study, more studies, especially studies of under-represented populations such as AA and Hispanics are needed to confirm our findings.
