Antidepressants include many different classes of drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). Several studies suggest that alcohol reduces antidepressant efficacy and exacerbates CNS side effects, though the pharmacokinetic interactions between alcohol and these drugs are not fully understood (266).
