dramatic impact than Girk1 ablation on synaptic Girk currents, which likely account for a small fraction of the somatodendritic currents measured in most studies. In support of this contention, a significant fraction of Girk2 protein, but not Girk1, is found within the postsynaptic specialization at excitatory synapses (Koyrakh et al. 2005; Marker et al. 2006). Clearly, understanding the more subtle differences between Girk1−/− and Girk2−/− mice reported in this study and other studies will require more selective genetic and/or pharmacologic approaches.
