This study suggests evidence for two new loci associated with two dimensions of personality: an intergenic region 135kb downstream from RASA1 on 5q14.3 for Openness to Experience and the KATNAL2 gene region on 18q21.1 for Conscientiousness. However, these loci were not unequivocally replicated. The KATNAL2 gene was also significant in the gene-based test. However, in the replication samples the effect did not reach a level of significance, although there was a consistency of direction of effects Thus, KATNAL2 might present a novel gene for personality. It should be noted however that even if the signal represents a true finding, the effect size is small. No genome-wide significant results were found for Neuroticism, Extraversion and Agreeableness.
