In Figure 4 the genes APOL1 and MYH9 are represented, together with the location of the recombination hotspots which were predicted from Hapmap data. The main recombination hotspot between APOL1 and MYH9 has been estimated to have an intensity of 0.2cm from Hapmap data. Stated differently, this means that variants on different sides of the hotspot are farther away a genetic distance equivalent to a physical distance of approximately 200kb, while the 3′ ends of the two genes are less than 20kb away from each other. It is clear from this picture that strong associations are still detected even after correction for ancestry from different linkage disequilibrium blocks. Supplementary Figures 1 and 2 show patterns of linkage disequilibrium for the African Yoruba population from Hapmap and the European population from Hapmap.
