metabolic responses, and glycosylation and glycoprotein metabolism (figure 2C, groups 1, 2, 6 and 7). However, untreated Pparα−/− and Pparαhep−/− mice showed marked differences (figure 2C, groups 3, 4, 8 and 9). This implies that the absence of extrahepatic PPARα has a significant impact on the liver transcriptional profile and underscores the relevance of Pparαhep−/− mice to define the hepatocyte autonomous role of the receptor in the control of liver function.
