Descriptive statistics by risk group are summarized in Table 1. For survival models where no differences were observed between AD and DD risk groups (A1 versus D1, A2 versus D2, A3 versus D3), a combined phenotype was examined: either DD or AD. Results of Cox regression models predicting onset of alcohol use, transition from use to first AD symptom, and transition from use to AD diagnosis are shown in Tables 2–4, respectively. For each outcome, three models are presented. In Model I, risk group only was modeled. In Model II, parental separation was included; and in Model III, control variables including maternal substance history, socio-demographic characteristics, and comorbid psychopathology and childhood trauma were added. Effects specific to risk group and parental separation are shown in Tables 2–4; effects of all predictors, including all control variables, are presented in Supplementary Tables 1–3.
