regulatory information at promoters on a genome-wide scale. We found genetic and epigenetic signatures unique to protein-coding and lncRNA genes, respectively. These divergent promoter grammars may help to explain the observed differential and highly tissue- and condition-specific transcriptional regulation of lncRNA genes compared to their protein-coding counterparts in the same pathways. To our knowledge, this is the first demonstration that human lncRNA and protein-coding gene promoters contain sufficiently dissimilar information to be consistently distinguished with high accuracy. Our results summarily suggest the existence of distinct regulatory programs for these two gene groups.
