dominant scenario for use of GAWMerge, the WGS is a substantial strength, accounting for all the array genotyped variants except for technology based regional loss of variants. With our strategy of WGS data as public controls for GWAS, there will be regional loss in specific areas depending on the array technology design and quality control of the sequencing. A complete analysis of different regional genetic variants covered specifically by array-genotyping platforms or sequencing will be beneficial to calibrate the application of GAWMerge in the future30,31.
