Chunk #30 — Potential Biological Mechanism of Hippocampal Sensitivity to AUDs: Impact of Altered GluN and GABAR Signaling in the Hippocampus on Adult Neurogenesis — Regulation of Neurogenesis by Alcohol
neurons in the DG (169, 171). This difference could be attributed to differences in BALs and negative affect symptoms resulting from the exposure paradigm (gavage vs. CIE). Unfortunately, there is no conclusive evidence linking aberrant neurogenesis subsequent to alcohol dependence and impaired hippocampal cognitive function. Future studies will be required to demonstrate the plausibility of this mechanism as an underlying explanation for the deleterious effect of alcohol dependence on hippocampal function.
