CRF can induce a slowly developing, but transient, potentiation of NMDAR-mediated synaptic transmission (Ungless et al. 2003). This effect involves the CRF2R and activation of the protein kinase C pathway and the requirement of CRF-BP. However, the effect of CRF is restricted to a subset of dopamine neurons expressing large Ih currents (Ungless et al. 2003).
