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Chunk #38 — Results and discussion — Comparing bias across libraries — Coverage complementarity

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Characterizing and measuring bias in sequence data.
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0.075%, compared to 0.54% and 0.27%, respectively, for the two technologies taken separately. Similar improvements occurred for E. coli with other platform combinations. However, for the other organisms, for the technologies tested, combining data did not reduce the overall level of bias. In most cases, one technology had much lower bias than the other and mixing tended to result in an intermediate level of bias. Therefore, in these cases, mixing provided no coverage benefit; lower bias could have been achieved by only using data from the lower bias technology.