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Chunk #8 — PROBLEMS WITH PHENOTYPE DEFINITION IN ADHD

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Twin studies and their implications for molecular genetic studies: endophenotypes integrate quantitative and molecular genetics in ADHD research.
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variance to ADHD behavioral assessments decrease the precision with which ADHD symptoms measure the underlying genetic liability for ADHD. In association and linkage studies, statistical power increases with the effect size of the quantitative trait locus.29,30 Thus a precise definition of ADHD, which measures as accurately as possible the trait of interest, remains a crucial issue in increasing the success of molecular genetic studies.31