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Chunk #33 — Discussion

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Genome-wide time-to-event analysis on smoking progression stages in a family-based study.
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The progression of smoking behavior from initiation to persistent smoking or cessation is a complex process involving multiple factors. Although some of the genetic factors related to smoking quantity and ND have been identified, we have only began to understand the underlying genome‐wide genetic effects on the development of smoking behavior. In this study, we identified novel SNPs associated with three specific transitions in smoking behavior in a Finnish twin family sample (N = 1962).