Chunk #31 — Discussion

Source

Alcohol use disorder causes global changes in splicing in the human brain.

Embedded

yes

Text

In sum, we showed that AUD markedly perturbs splicing in the superior frontal cortex, nucleus accumbens, basolateral amygdala, and central nucleus of the amygdala in a genome-wide fashion. Mechanistically, mis-splicing may be mediated by increased expression of HSPA6 and/or altered expression of splicing-related lncRNAs.