rather low inter-correlation (R2=0.06) yielded p-values less than 10−4 in the interaction model. Other examples of genes containing SNPs that were highly significant in the interaction model, even though they did not reach p<0.05 in the main effect model are DBI, ADCY8, VAPA and GABRR1. Two genes, DBH and KCNB1 were among the top findings in the interaction model, despite the fact that their p-values in the main-effect model were actually lower, suggesting that these SNPs exhibit robust main effects across all values of rAOS. Finally, several SNPs exhibited relatively low p-values in the main effect model but yielded improved fits under the interaction model, suggesting statistically significant (or near-significant) interactions; these included SNPs from CHRNA5, MAP3K4, KCNJ6.
