In our primary analysis, only chromosomes 2 and 7 were found to have LOD scores over 1.8 at stage 1. Tables 1 and 2 show the results of the combined two-point linkage and trait association analysis (QPDT) for these two chromosomes. For the stage 2 association analyses, the tables report only those SNPs significant at the 0.01 level. We note that while multiple SNPs throughout the linked regions were significant at the 0.05 level, only one SNP on chromosome 2 and multiple SNPs on chromosome 7 gave association results significant at the 0.01 level. Table 3 lists the results for the additional two-point regression analysis performed on chromosome 4 by MERLIN-REGRESS and the QPDT results computed by UNPHASED for SNPs in the linkage regions detected by the regression. The maximal LOD of 2.14 occurred at 97.4 Mb (100.4 cM).
