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Chunk #12 — Results — Power gain from genotype imputation

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A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines.
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The increase of power through imputation and PC adjustment was largest for transcripts with heritability (H2; narrow sense total heritability) (Dixon et al. 2007) in the middle range (Fig. 5). The biggest gain in the MRCA data set was observed at 52% of transcripts with H2 between 0.6 and 0.7 mapped in locally or at a distance after PC adjustment and imputation compared with 20% before the improved analysis. For the MRCE data set, the most improved category was for H2 between 0.3 and 0.4, with increments from 15% to 66%.