PHF3 and PTP4A1 might also influence alcohol dependence by interacting with other genes. Expression of PHF3 and PTP4A1 transcripts was significantly correlated with expression of many alcoholism-related genes in brain, including those in the dopaminergic, serotoninergic, GABAergic, glutamatergic, histaminergic and endocannabinoid systems [6], [17], [18], [19], [20], [21]. These findings suggested that PHF3 and PTP4A1 might also be implicated in alcohol dependence via the classical neurotransmission systems or metabolic pathways.
