We performed a case-only analysis testing all variants in LD with the index variant (19 SNPs; r2 >0.7) for association with age at first CUD diagnosis. This analysis suggested the risk alleles to be associated with earlier age at first diagnosis (most significant SNP: rs35236974, P=0.020). On average CUD cases homozygous for the protective allele got their diagnosis (mean age: 22.41; st.dev=3.63) one year later than CUD cases having at least one risk allele (mean age: 21.01; st.dev=3.56).
