as myelinogenic cells that ensheathed resident axons (Douvaras et al. 2014; Fossati and Douvaras 2014). While the analysis was too early to identify any stigmata of PPMS, the authors were able to report success in the establishment of mice chimerized with PPMS-derived oligodendroglia. Although it remains unclear whether such mice will prove informative in the study of MS, it seems likely that mice chimerized with hGPCs derived from patients suffering from a broad variety of hereditary myelin disorders will ultimately prove informative in defining the respective roles of those glia in disease pathogenesis.
