The primary research questions concerned the relationship between parental alcoholism and offspring psychiatric illness, with offspring grouped by the presence or absence of paternal and maternal alcoholism and stratified by gender. To investigate, we first examined the association between paternal and maternal alcoholism and sociodemographic variables - age, gender, race/ethnicity, education, employment status, annual household income, and whether offspring had grown up with both biological parents. This was done to identify possible confounding factors for multivariable models. Next, we calculated gender-specific, unadjusted, weighted rates of psychiatric disorders with two separate stratifications, first by the absence or presence of paternal alcoholism and second by the absence or presence of maternal alcoholism. Finally, we fit a series of logistic regression models where psychiatric disorders were the dependent variables of interest and gender, the absence or presence of parental alcoholism, and the interaction between gender and the absence or presence of parental alcoholism were the independent variables of interest, adjusting for previously identified potentially confounding factors. Models were fit separately for maternal and paternal history of alcoholism. Similar to other NESARC analyses (Grant
