Chunk #33 — Methods — LCV model

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Distinguishing genetic correlation from causation across 52 diseases and complex traits.

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In detail, the LCV model assumes that there exist scalars q1, q2 and a distribution (π, γ1, γ2) such that (3)(α1,α2)=(q1π+q2π)+(γ1,γ2),whereπ⊥(γ1,γ2)and(γ1,γ2)~(−γ1,γ2)~(γ1,−γ2).