Chunk #17 — 2. Methods — 2.3. Statistical methods

Source

Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.

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To address multiple testing issues in these analyses, a FDR (false discovery rate) based procedure (Benjamini and Hochberg, 1995) was implemented using the SAS package to obtain adjusted P-values. The FDR is estimated as the proportion of expected false rejections over the total number of rejections and is determined from the observed P-value distribution.