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Chunk #35 — Results — Power versus Coverage

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Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip.
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In one sense this shouldn't be surprising. Coverage is measured to a hard threshold: so if SNP has r 2 of 0.85 to its best proxy on one chip and 0.75 to its best proxy on another chip, it will be counted as “covered” by one chip but not by the other, whereas the difference in power is small. Coverage statistics also do not depend on study size or disease model.