cases and 26,561 controls) and UK BiLEVE (COPD definition based on spirometry, 9,563 moderate-severe cases, 27,387 controls). UK BiLEVE COPD cases and controls were only used for single variant COPD association tests for the subset of 47 variants discovered independently from UK BiLEVE (that is excluding the 43 variants discovered using the UK BiLEVE data described in this paper and 5 variants reported in our previous study in the UK BiLEVE population16). Across all 95 variants, 51 showed nominal COPD association (P<0.05) and 30 showed associations with COPD susceptibility reaching a Bonferroni corrected threshold for 95 tests (P<5.26x10-4, Supplementary Table 10). Of these 30, 27 were variants discovered independently from UK BiLEVE and 3 were from the 48 lower powered association tests not including UK BiLEVE cases and controls.
