and CNR2 (cannabinoid receptors), and ADH1B (Alcohol Dehydrogenase). We imposed a MAF filter of 0.01 and a sample size filter that selected, for each GWAS, the SNPs with sample sizes larger than two-thirds of the ninth decile of the GWAS’s sample size. MTAG limited the analysis to the 5,869,552 SNPs analyzed in all GWAS (and that satisfied these filters). To identify approximately independent lead SNPs for general risk tolerance, we applied the clumping algorithm described above. The Supplementary Note, Supplementary Table 10, and Supplementary Fig. 7 provide further details.
