GRK6, HDAC3, PPP2R1B, and PRKACB (see Supplementary Figs. S3–S4). The GRIA2 gene showed differential splicing in a putative ‘flip flop’ splicing site (see Supplementary Fig. S5), which alters the rate of AMPA receptor opening38,39 and has been implicated with chronic alcohol use in primates40. We found 53 differentially expressed genes associated with AUD (all padj < 0.05; see Supplementary File S5). Note, no differentially expressed gene was differentially spliced.
