Then, because the data herein are substantially larger than existing brain eQTL datasets that were therefore more limited in power for eQTL discovery, we focused on testing the sensitivity of our eQTL towards recapitulating publicly available eQTL. To robustly assess this sensitivity, we considered the eQTL P values from our CMC cohort with regards to the eQTL associations described in each public database we had curated. We scored the overlap using π1, the proportion of non-null hypotheses (as estimated by the ‘qvalue’ package in R) among the distribution of CMC P values for the database eQTL SNP-gene association pairs.
