Data were culled from the Study of Addiction: Genetics and Environment (SAGE) genome-wide association study (GWAS). Complete data for this study were available for a total of 2,533 Caucasian participants in the SAGE (dbGaP study accession phs000092 v1.p1) data set. Alcohol dependent cases and non-alcoholic controls were selected from three large datasets: (1) Collaborative Study on the Genetics of Alcoholism (COGA);(2) Family Study of Cocaine Dependence (FSCD); and (3) Collaborative Genetic Study of Nicotine Dependence (COGEND). Of the 2,533 Caucasian participants identified, and for whom complete data were available, 1,167 were classified as alcohol dependent “cases” and 1,366 as “controls.” The sample characteristics are presented in Table 1. A detailed demographic description of the SAGE sample has been provided elsewhere (Bierut et al., 2010). All subjects provided written informed consent for genetic studies and agreed to have their DNA and clinical data available to investigators through the National Institutes of Health repositories. All data for this study were de-identified.
