Genetic variants were pruned (R2<0.001) and the remaining genetic variants (or proxies [R2≥0.8] when an instrumental SNP was not available in the other GWAS) were then identified in GWAS summary-level data of the outcome variable (gene-outcome association). Note that not all independent SNPs identified in the exposure dataset have been included in the analyses, because not all exposure SNPs or their proxies were also available in the outcome dataset and because some SNPs were palindromic (see Supplementary Table S7).
