Chunk #74 — Dissection of the molecular mechanisms linking maternal behavior and active demethylation of GR exon 17 promoter in the hippocampus

Source

Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

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yes

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these manipulations abolished the ability of NGFIA to activate and demethylate the GR exon 17 promoter. These experiments provide a molecular mechanism on how demethylation is triggered to specific sequences. The outstanding question is to determine how NGFIA triggers demethylation upon binding to specific sequences. One possibility is that NGFIA directly recruits a demethylase to the gene or that, as proposed before, it recruits a HAT that increases acetylation, thus increasing the accessibility to demethylase as proposed before.