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Chunk #17 — Methods — Effects of risk factors on disease outcomes

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A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
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Evidence for the RR of diarrhoea from unimproved water and sanitation is complicated by the complexity of available epidemiological studies, since the comparison groups varied greatly between studies. The comparison group used varied widely. For example, some studies compare an improved water source (eg, piped water) with an unimproved water source (eg, river water); in other studies the comparison is between two different types of improved water source (eg, piped water vs a protected well). Furthermore, studies often examine a combination of water, sanitation, and hygiene interventions. Previous reviews have yielded conflicting results about the magnitude of the effect sizes.127–131