Chunk #3 — Background — The disease being simulated: Kofendrerd Personality Disorder (KPD)

Source

Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

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From the point of view of searching for disease genes, KPD and the endophenotypes associated with it probably represent a much stronger genetic/etiologic connection than exists with most actual common diseases, and thus the causative genes and the interactions should be easier to discover.