Studies examining potential interactions between measured genes and environment153, 154 are also becoming more common. For example, Dick et al.155, 156 reported that the association of GABRA2 and CHRM2 variants with externalizing trajectories diminished with high levels of parental monitoring. In addition to environment exacerbating genetic vulnerability, there is also evidence for the stress-buffering effects of genotype. Nelson et al.157 found that the effect of childhood sexual abuse on alcoholism was buffered in those carrying the H2 haplotype of the gene encoding the corticotrophin-releasing factor (CRHR1).
