Using a different verbal fluency fMRI paradigm, a sentence completion task, Whalley et al. found decreased medial frontal and cerebellar activation [63] and aberrant coupling between Broca's area and parietal cortex in subjects at high genetic risk [64]. The effects of three risk genes were explored with this paradigm (G72, NRG1, COMT) (Supplementary Table 2.D) [65–67] and only NRG1 was reported to modulate the medial frontal gyrus [66], although the relationship of this area with verbal fluency processing is not clear.
