We performed within-ancestry fine mapping for the 85 clumped regions with independent lead variants in EUR (Supplementary Tables 5 and 6). A median number of 115 SNPs were included in each region to estimate the credible sets with 99% posterior inclusion probability (PIP) of causal variants. After fine mapping, the median number of SNPs constituting the credible sets was reduced to 20. Among the 85 regions, there were 5 credible sets that include only a single variant with PIP ≥99% (presumably indicating successful identification of specific causal variants): rs1260326 in GCKR, rs472140 and rs1229984 in ADH1B, rs2699453 (intergenic) and rs2098112 (intergenic). Another 19 credible sets contained ≤5 variants (Fig. 2a).
