similar to those for rs16969968. (An analog of Table 2, replacing rs16969968 throughout with rs1061730, can be found in Supplemental Table S2.) We cannot say which, if either, of these two SNPs is biologically linked to smoking behavior. We can only say that they are representatives of a cluster of variants in tight linkage disequilibrium that display these effects. Further research in the lab will be required to identify the causative variants definitively.