and illicit drug use and dependence for individuals who reported none, one, two, or three or more DUIs. We anticipated that examining gradations of disorder within a combination of two high-risk indicators, DUI and family vulnerability, might provide useful information for clinical research about individuals with chronic and severe alcohol problems. In addition, any gender differences found in this high-risk sample were expected to contribute to the literature on alcohol dependence among women at the more severe end of the alcohol dependence spectrum.