After adjusting for the effects of other covariates, fewer factors significantly predicted treatment-seeking. Across all SUDs, having previously sought treatment for another SUD-predicted treatment. In the multivariable models, a history of prior mental health treatment also predicted treatment for alcohol abuse and drug dependence. A later age of onset, having never been married and receiving less than a college education continued to increase the probability of treatment-seeking for alcohol abuse and dependence, but not for drug abuse or dependence.