In addition to FAAH, monoglyceride lipase (MGL) is responsible for the hydrolysis of 2-AG and other lipids [69-71]. The gene encoding this enzyme, MGLL, is 131 kb long, has 8 exons, lies on 3q21.3 and has been implicated in at least two independent studies of cannabis use disorders [20,22]. In one association study, polymorphisms in MGLL were not found to be associated with alcoholism in Japanese adults [65].
