rs2273500 was next evaluated for its association with lung cancer in 28 998 participants from six European-ancestry case–control samples (Supplementary Table 11).47 rs2273500-C was associated with increased lung cancer risk: meta-analysis odds ratio=1.06 (95% confidence interval 1.00–1.12), particularly for squamous cell carcinoma of the lung. However, the association between rs2273500-C and lung cancer was likely mediated by cigarette smoking, as it was no longer associated with lung cancer when adjusted for smoking (Supplementary Table 12).
